Protein-tyrosine kinase 2-beta · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein-tyrosine kinase 2-beta shows late clinical disease relevance led by ovarian cancer. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q14289. Start with ovarian cancer, then reuse UniProt Q14289 as the stable protein anchor across project notes and exports.
Start with ovarian cancer, then reuse UniProt Q14289 as the stable protein anchor across project notes and exports.
Protein-tyrosine kinase 2-beta shows late clinical disease relevance led by ovarian cancer. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with ovarian cancer because it currently carries late clinical support. Linked drugs include DEFACTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProtein-tyrosine kinase 2-beta
Review this target as Protein-tyrosine kinase 2-beta, mapped to UniProt Q14289. Sequence length is 1009 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein-tyrosine kinase 2-beta as ChEMBL target CHEMBL5469, mapped to UniProt Q14289. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Protein-tyrosine kinase 2-beta is the right protein anchor across sources, using UniProt Q14289 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why ovarian cancer is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Protein-tyrosine kinase 2-beta |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14289 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein-tyrosine kinase 2-beta |
| UniProt Accession | Q14289 |
| Component Type | Protein |
| Sequence Length | 1009 aa |
Protein-tyrosine kinase 2-beta
Review this target as Protein-tyrosine kinase 2-beta, mapped to UniProt Q14289. Sequence length is 1009 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Protein-tyrosine kinase 2-beta shows late clinical disease relevance led by ovarian cancer. 5 more disease programs remain visible in the same review block.
Start review with ovarian cancer because it currently carries late clinical support. Linked drugs include DEFACTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3137331 | 9.7 | IC50 | 0.2 | Clinical |
| CHEMBL4862042 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3949755 | 9.17 | IC50 | 0.67 | Preclinical |
| CHEMBL3958414 | 9.08 | IC50 | 0.84 | Preclinical |
| CHEMBL3956954 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL509032 | 8.96 | Kd | 1.1 | Preclinical |
| CHEMBL3987106 | 8.88 | IC50 | 1.31 | Preclinical |
| CHEMBL1084546 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL3899046 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL3969464 | 8.81 | IC50 | 1.55 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 258 | 270 | 6.1 |
| cell-based format | 37 | 35 | 7.3 |
| assay format | 34 | 9 | 7.2 |
| subcellular format | 20 | 25 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 57 | 6.5 |