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Target Snapshot

CHEMBL5482992 Target Snapshot

HDAC6-ISG15 · PROTEIN-PROTEIN INTERACTION · Homo sapiens

2Compounds
1Assays
0Approved Drugs
2.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UBN7. Use UniProt Q9UBN7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UBN7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HDAC6-ISG15 as ChEMBL target CHEMBL5482992, mapped to UniProt Q9UBN7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HDAC6-ISG15
PROTEIN-PROTEIN INTERACTION · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5482992
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UBN7
Protein deacetylase HDAC6
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HDAC6-ISG15 is the right protein anchor across sources, using UniProt Q9UBN7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein deacetylase HDAC6
UniProt AccessionQ9UBN7
Component TypeProtein
Sequence Length1215 aa

Protein deacetylase HDAC6

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as HDAC6-ISG15, mapped to UniProt Q9UBN7. ChEMBL maps the protein component as Protein deacetylase HDAC6. Sequence length is 1215 aa.

Mapped IDQ9UBN7
Review nameHDAC6-ISG15
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5410606 5.72 EC50 1900.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine