Rho-associated protein kinase 2 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q62868. Use UniProt Q62868 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q62868 as the stable identity anchor, then attach disease evidence before program review.
Rho-associated protein kinase 2
Review this target as Rho-associated protein kinase 2, mapped to UniProt Q62868. Sequence length is 1388 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Rho-associated protein kinase 2 as ChEMBL target CHEMBL5490, mapped to UniProt Q62868. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Rho-associated protein kinase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q62868 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Rho-associated protein kinase 2 |
| UniProt Accession | Q62868 |
| Component Type | Protein |
| Sequence Length | 1388 aa |
Rho-associated protein kinase 2
Review this target as Rho-associated protein kinase 2, mapped to UniProt Q62868. Sequence length is 1388 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3221812 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL3221808 | 7.37 | IC50 | 43.0 | Preclinical |
| CHEMBL5281208 | 6.62 | IC50 | 240.0 | Preclinical |
| CHEMBL104264 | 6.57 | IC50 | 270.0 | Preclinical |
| CHEMBL3221810 | 6.39 | IC50 | 411.0 | Preclinical |
| CHEMBL3221816 | 6.29 | IC50 | 519.0 | Preclinical |
| CHEMBL559147 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL3221814 | 6.05 | IC50 | 900.0 | Preclinical |
| CHEMBL38380 | 5.72 | IC50 | 1900.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 26 | 0 | — |
| assay format | 18 | 0 | — |
| cell-based format | 11 | 9 | 6.5 |
| organism-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 1 | 0 | — |