Wee1-like protein kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Wee1-like protein kinase shows clinical signal disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P30291. Start with neoplasm, then reuse UniProt P30291 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P30291 as the stable protein anchor across project notes and exports.
Wee1-like protein kinase shows clinical signal disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include ADAVOSERTIB, AZENOSERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyWee1-like protein kinase
Review this target as Wee1-like protein kinase, mapped to UniProt P30291. Sequence length is 646 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Wee1-like protein kinase as ChEMBL target CHEMBL5491, mapped to UniProt P30291. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Wee1-like protein kinase is the right protein anchor across sources, using UniProt P30291 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Wee1-like protein kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P30291 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Wee1-like protein kinase |
| UniProt Accession | P30291 |
| Component Type | Protein |
| Sequence Length | 646 aa |
Wee1-like protein kinase
Review this target as Wee1-like protein kinase, mapped to UniProt P30291. Sequence length is 646 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Wee1-like protein kinase shows clinical signal disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include ADAVOSERTIB, AZENOSERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5933715 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5876377 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5831450 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5278196 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4441166 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL6065998 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5963536 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5956499 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5759393 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5284925 | 9.7 | IC50 | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 199 | 957 | 7.4 |
| cell-based format | 34 | 100 | 7.1 |
| assay format | 30 | 55 | 8.2 |
| subcellular format | 19 | 15 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 20 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 3 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |