Free fatty acid receptor 2 · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Free fatty acid receptor 2 shows clinical signal disease relevance led by ulcerative colitis. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O15552. Start with ulcerative colitis, then reuse UniProt O15552 as the stable protein anchor across project notes and exports.
Start with ulcerative colitis, then reuse UniProt O15552 as the stable protein anchor across project notes and exports.
Free fatty acid receptor 2 shows clinical signal disease relevance led by ulcerative colitis. 1 linked drug remains visible in the same block.
Start review with ulcerative colitis because it currently carries clinical signal support. Linked drugs include GLPG-0974. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyFree fatty acid receptor 2
Review this target as Free fatty acid receptor 2, mapped to UniProt O15552. Sequence length is 330 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Free fatty acid receptor 2 as ChEMBL target CHEMBL5493, mapped to UniProt O15552. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Free fatty acid receptor 2 is the right protein anchor across sources, using UniProt O15552 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why ulcerative colitis is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Free fatty acid receptor 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15552 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Free fatty acid receptor 2 |
| UniProt Accession | O15552 |
| Component Type | Protein |
| Sequence Length | 330 aa |
Free fatty acid receptor 2
Review this target as Free fatty acid receptor 2, mapped to UniProt O15552. Sequence length is 330 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Free fatty acid receptor 2 shows clinical signal disease relevance led by ulcerative colitis.
Start review with ulcerative colitis because it currently carries clinical signal support. Linked drugs include GLPG-0974. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5748267 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5838011 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5838437 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5885845 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5896488 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5756440 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL5777334 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL5808688 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL5828279 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL5856367 | 8.7 | EC50 | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 33 | 207 | 6.2 |
| assay format | 7 | 0 | — |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 12 | 1 | 4.6 |
| cell-based format | 7 | 315 | 7.2 |
| assay format | 5 | 108 | 6.2 |
| tissue-based format | 1 | 1 | 6.3 |