Modulator of drug activity A · SINGLE PROTEIN · Escherichia coli O157:H7
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As of 2026-09-14Protein identity stays anchored to UniProt Q8X6S1. Use UniProt Q8X6S1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8X6S1 as the stable identity anchor, then attach disease evidence before program review.
Oxygen-insensitive NADPH nitroreductase
Review this target as Modulator of drug activity A, mapped to UniProt Q8X6S1. ChEMBL maps the protein component as Oxygen-insensitive NADPH nitroreductase. Sequence length is 240 aa.
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This review treats Modulator of drug activity A as ChEMBL target CHEMBL5502, mapped to UniProt Q8X6S1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Modulator of drug activity A |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli O157:H7 |
| UniProt | Q8X6S1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Oxygen-insensitive NADPH nitroreductase |
| UniProt Accession | Q8X6S1 |
| Component Type | Protein |
| Sequence Length | 240 aa |
Oxygen-insensitive NADPH nitroreductase
Review this target as Modulator of drug activity A, mapped to UniProt Q8X6S1. ChEMBL maps the protein component as Oxygen-insensitive NADPH nitroreductase. Sequence length is 240 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL23065 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL22592 | 6.72 | IC50 | 190.0 | Preclinical |
| CHEMBL23216 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL23612 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL23330 | 6.05 | IC50 | 890.0 | Clinical |
| CHEMBL23355 | 5.72 | IC50 | 1900.0 | Preclinical |
| CHEMBL23558 | 5.47 | IC50 | 3400.0 | Preclinical |
| CHEMBL23938 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL22728 | 5.12 | IC50 | 7500.0 | Preclinical |
| CHEMBL23066 | 5.03 | IC50 | 9300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 16 | 5.5 |