Review anchor
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
Evidence Snapshot
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CHEMBL5508
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity tyrosine-phosphorylation-regulated kinase 1A as ChEMBL target CHEMBL5508, mapped to UniProt Q63470. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL5508
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q63470
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProt accession via ChEMBL component mapping
As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-14
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Dual specificity tyrosine-phosphorylation-regulated kinase 1A matters
Dual specificity tyrosine-phosphorylation-regulated kinase 1A is reviewed as Dual specificity tyrosine-phosphorylation-regulated kinase 1A (UniProt Q63470); the current evidence base includes 0 approved drugs, 1527 compounds, and 91 assays, with lead potency reaching pChEMBL 8.6.
Protein context
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Sequence length is 763 aa.
Review this target as Dual specificity tyrosine-phosphorylation-regulated kinase 1A, mapped to UniProt Q63470. Sequence length is 763 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt Q63470
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 0 approved drugs, 1527 compounds, and 91 assays for this target. The dominant activity type is IC50. CHEMBL3102950 is the current potency anchor at pChEMBL 8.6.
Use CHEMBL3102950 as the tractability anchor when discussing potency (pChEMBL 8.6).
Activity source · ChEMBL 36 via Core Engine
pChEMBL 8.6
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Dual specificity tyrosine-phosphorylation-regulated kinase 1A matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q63470, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
1527
Total Compounds
91
Total Assays
0
Approved Drugs
IC50: 533.0, KI: 7.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL3102950
|
8.6 | Ki | — |
|
|
No preferred name
CHEMBL3102952
|
8.5 | IC50 | — |
|
|
No preferred name
CHEMBL3102951
|
8.3 | Ki | — |
|
|
No preferred name
CHEMBL3102953
|
8.1 | Ki | — |
|
|
No preferred name
CHEMBL1802358
|
8.0 | IC50 | — |
Source Header