Huntingtin · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P42858. Use UniProt P42858 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P42858 as the stable identity anchor, then attach disease evidence before program review.
Huntingtin
Review this target as Huntingtin, mapped to UniProt P42858. Sequence length is 3142 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Huntingtin as ChEMBL target CHEMBL5514, mapped to UniProt P42858. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Huntingtin is the right protein anchor across sources, using UniProt P42858 as the stable mapping.
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| Preferred Name | Huntingtin |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P42858 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Huntingtin |
| UniProt Accession | P42858 |
| Component Type | Protein |
| Sequence Length | 3142 aa |
Huntingtin
Review this target as Huntingtin, mapped to UniProt P42858. Sequence length is 3142 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4875017 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL4878942 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL4847156 | 8.68 | IC50 | 2.1 | Preclinical |
| CHEMBL4863336 | 8.68 | IC50 | 2.1 | Preclinical |
| CHEMBL4867927 | 8.66 | IC50 | 2.2 | Preclinical |
| CHEMBL4859053 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL5179682 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL5195936 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL5175104 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL5288592 | 7.0 | Kd | 100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 32 | 25 | 6.4 |
| cell-based format | 22 | 15 | 5.5 |
| assay format | 5 | 1 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 0 | — |
| cell-based format | 1 | 0 | — |