Lysophosphatidylserine lipase ABHD12 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8N2K0. Use UniProt Q8N2K0 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8N2K0 as the stable identity anchor, then attach disease evidence before program review.
Lysophosphatidylserine lipase ABHD12
Review this target as Lysophosphatidylserine lipase ABHD12, mapped to UniProt Q8N2K0. Sequence length is 398 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lysophosphatidylserine lipase ABHD12 as ChEMBL target CHEMBL5516, mapped to UniProt Q8N2K0. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lysophosphatidylserine lipase ABHD12 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8N2K0 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysophosphatidylserine lipase ABHD12 |
| UniProt Accession | Q8N2K0 |
| Component Type | Protein |
| Sequence Length | 398 aa |
Lysophosphatidylserine lipase ABHD12
Review this target as Lysophosphatidylserine lipase ABHD12, mapped to UniProt Q8N2K0. Sequence length is 398 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL175247 | 7.1 | IC50 | 80.0 | Approved |
| CHEMBL4757488 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL4164954 | 5.68 | IC50 | 2100.0 | Preclinical |
| CHEMBL4780771 | 5.68 | IC50 | 2100.0 | Preclinical |
| CHEMBL4167303 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL5653589 | 4.98 | Kd | 10463.58 | Preclinical |
| CHEMBL465 | 4.94 | IC50 | 11600.0 | Approved |
| CHEMBL4845760 | 4.85 | IC50 | 14100.0 | Preclinical |
| CHEMBL4862731 | 4.54 | IC50 | 28800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 21 | 8 | 6.0 |
| assay format | 8 | 0 | — |
| single protein format | 2 | 1 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |