Misshapen-like kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8N4C8. Use UniProt Q8N4C8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8N4C8 as the stable identity anchor, then attach disease evidence before program review.
Misshapen-like kinase 1
Review this target as Misshapen-like kinase 1, mapped to UniProt Q8N4C8. Sequence length is 1332 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Misshapen-like kinase 1 as ChEMBL target CHEMBL5518, mapped to UniProt Q8N4C8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Misshapen-like kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8N4C8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Misshapen-like kinase 1 |
| UniProt Accession | Q8N4C8 |
| Component Type | Protein |
| Sequence Length | 1332 aa |
Misshapen-like kinase 1
Review this target as Misshapen-like kinase 1, mapped to UniProt Q8N4C8. Sequence length is 1332 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.63 | IC50 | 0.235 | Preclinical |
| CHEMBL388978 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL379975 | 8.9 | Ki | 1.259 | Preclinical |
| CHEMBL4746566 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL1986943 | 8.5 | Ki | 3.162 | Preclinical |
| CHEMBL288441 | 8.49 | Kd | 3.2 | Approved |
| CHEMBL603469 | 8.44 | Kd | 3.6 | Clinical |
| CHEMBL1991674 | 8.4 | Ki | 3.981 | Preclinical |
| CHEMBL1998159 | 8.4 | Ki | 3.981 | Preclinical |
| CHEMBL1996980 | 8.3 | Ki | 5.012 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 252 | 53 | 6.8 |
| assay format | 29 | 6 | 6.7 |
| cell-based format | 29 | 12 | 6.3 |
| subcellular format | 10 | 11 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 344 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 6.1 |