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Target Snapshot

CHEMBL5534 Target Snapshot

Primary amine oxidase · SINGLE PROTEIN · Pisum sativum

9Compounds
3Assays
0Approved Drugs
9.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q43077. Use UniProt Q43077 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q43077 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Primary amine oxidase as ChEMBL target CHEMBL5534, mapped to UniProt Q43077. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Primary amine oxidase
SINGLE PROTEIN · Pisum sativum
As of 2026-09-14
ChEMBL target ID
CHEMBL5534
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q43077
Primary amine oxidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Primary amine oxidase is the right protein anchor across sources, using UniProt Q43077 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPrimary amine oxidase
UniProt AccessionQ43077
Component TypeProtein
Sequence Length674 aa

Primary amine oxidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Primary amine oxidase, mapped to UniProt Q43077. Sequence length is 674 aa.

Mapped IDQ43077
Review namePrimary amine oxidase
OrganismPisum sativum
Assay Mix

Activity Type Distribution

IC509.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL534914 6.15 IC50 710.0 Preclinical
CHEMBL537624 5.03 IC50 9300.0 Preclinical
CHEMBL534467 4.77 IC50 17000.0 Preclinical
CHEMBL537623 4.26 IC50 55000.0 Preclinical
CHEMBL541126 4.05 IC50 89000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
7
Tested Compounds
1
Assay Types
Binding — 3 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 7 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine