Dual specificity tyrosine-phosphorylation-regulated kinase 1B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9Y463. Use UniProt Q9Y463 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y463 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Review this target as Dual specificity tyrosine-phosphorylation-regulated kinase 1B, mapped to UniProt Q9Y463. Sequence length is 629 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity tyrosine-phosphorylation-regulated kinase 1B as ChEMBL target CHEMBL5543, mapped to UniProt Q9Y463. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y463 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
| UniProt Accession | Q9Y463 |
| Component Type | Protein |
| Sequence Length | 629 aa |
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Review this target as Dual specificity tyrosine-phosphorylation-regulated kinase 1B, mapped to UniProt Q9Y463. Sequence length is 629 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5093650 | 10.3 | Kd | 0.05 | Preclinical |
| CHEMBL2386744 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL2386770 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL2386747 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL2386745 | 9.23 | IC50 | 0.59 | Preclinical |
| CHEMBL3894571 | 9.23 | IC50 | 0.59 | Preclinical |
| CHEMBL1965660 | 9.2 | Ki | 0.631 | Preclinical |
| CHEMBL388978 | 9.02 | IC50 | 0.967 | Preclinical |
| CHEMBL5082044 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5083159 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 279 | 571 | 7.0 |
| assay format | 79 | 149 | 6.5 |
| cell-based format | 17 | 103 | 6.9 |
| tissue-based format | 5 | 0 | — |
| subcellular format | 1 | 1 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 13 | 6.8 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 1 | 5.9 |
| assay format | 2 | 203 | 5.9 |