Diacylglycerol lipase-alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y4D2. Use UniProt Q9Y4D2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y4D2 as the stable identity anchor, then attach disease evidence before program review.
Diacylglycerol lipase-alpha
Review this target as Diacylglycerol lipase-alpha, mapped to UniProt Q9Y4D2. Sequence length is 1042 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Diacylglycerol lipase-alpha as ChEMBL target CHEMBL5545, mapped to UniProt Q9Y4D2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Diacylglycerol lipase-alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y4D2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Diacylglycerol lipase-alpha |
| UniProt Accession | Q9Y4D2 |
| Component Type | Protein |
| Sequence Length | 1042 aa |
Diacylglycerol lipase-alpha
Review this target as Diacylglycerol lipase-alpha, mapped to UniProt Q9Y4D2. Sequence length is 1042 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4476210 | 9.6 | IC50 | 0.2512 | Preclinical |
| CHEMBL4581240 | 9.3 | IC50 | 0.5012 | Preclinical |
| CHEMBL3764017 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3897587 | 9.2 | IC50 | 0.631 | Preclinical |
| CHEMBL3906477 | 9.1 | IC50 | 0.7943 | Preclinical |
| CHEMBL3913807 | 9.1 | IC50 | 0.7943 | Preclinical |
| CHEMBL3954476 | 9.1 | IC50 | 0.7943 | Preclinical |
| CHEMBL4279328 | 9.1 | IC50 | 0.7943 | Preclinical |
| CHEMBL3765578 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL3970032 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 42 | 167 | 6.9 |
| single protein format | 5 | 5 | 6.6 |
| assay format | 1 | 22 | 5.6 |