Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL5552 Target Snapshot

Serine/threonine-protein kinase 25 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
554Compounds
210Assays
7Approved Drugs
146.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O00506. Use UniProt O00506 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O00506 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase 25 as ChEMBL target CHEMBL5552, mapped to UniProt O00506. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase 25
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5552
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O00506
Serine/threonine-protein kinase 25
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase 25 is the right protein anchor across sources, using UniProt O00506 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSerine/threonine-protein kinase 25
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtO00506
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase 25
UniProt AccessionO00506
Component TypeProtein
Sequence Length426 aa

Serine/threonine-protein kinase 25

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase 25, mapped to UniProt O00506. Sequence length is 426 aa.

Mapped IDO00506
Review nameSerine/threonine-protein kinase 25
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase III
7
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5025.0
KD121.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 8.72 IC50 1.9 Preclinical
CHEMBL3943675 7.92 IC50 12.0 Preclinical
CHEMBL180022 7.92 Kd 12.0 Approved
CHEMBL3770443 7.47 IC50 34.0 Preclinical
CHEMBL603469 7.01 Kd 97.0 Clinical
CHEMBL388978 6.96 Kd 110.0 Preclinical
CHEMBL5276146 6.68 IC50 211.0 Preclinical
CHEMBL535 6.54 Kd 290.0 Approved
CHEMBL1721885 6.44 Kd 360.0 Clinical
CHEMBL191003 6.44 Kd 360.0 Preclinical
Distribution

pChEMBL Value Distribution

12
5.0
9
5.5
10
6.0
7
6.5
4
7.0
2
7.5
1
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NERATINIB
CHEMBL180022
Approved 2017
Properties Compare Identifier
BOSUTINIB
CHEMBL288441
Approved 2012
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

210
Total Assays
32
Tested Compounds
1
Assay Types
Binding — 210 assays, 32 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 151 30 6.3
assay format 28 0 —
cell-based format 24 2 6.3
subcellular format 7 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine