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Target Snapshot

CHEMBL5556 Target Snapshot

C-X-C chemokine receptor type 4 · SINGLE PROTEIN · Rattus norvegicus

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77Compounds
6Assays
1Approved Drugs
80.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O08565. Use UniProt O08565 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O08565 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C-X-C chemokine receptor type 4 as ChEMBL target CHEMBL5556, mapped to UniProt O08565. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C-X-C chemokine receptor type 4
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL5556
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O08565
C-X-C chemokine receptor type 4
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C-X-C chemokine receptor type 4 is the right protein anchor across sources, using UniProt O08565 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameC-X-C chemokine receptor type 4
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtO08565
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC-X-C chemokine receptor type 4
UniProt AccessionO08565
Component TypeProtein
Sequence Length349 aa

C-X-C chemokine receptor type 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as C-X-C chemokine receptor type 4, mapped to UniProt O08565. Sequence length is 349 aa.

Mapped IDO08565
Review nameC-X-C chemokine receptor type 4
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5080.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL392423 9.0 IC50 1.0 Preclinical
CHEMBL237629 9.0 IC50 1.0 Preclinical
CHEMBL1802286 9.0 IC50 1.0 Preclinical
CHEMBL1802287 9.0 IC50 1.0 Preclinical
CHEMBL1802323 9.0 IC50 1.0 Preclinical
CHEMBL1802330 9.0 IC50 1.0 Preclinical
CHEMBL3896101 9.0 IC50 1.0 Preclinical
CHEMBL3912875 9.0 IC50 1.0 Preclinical
CHEMBL3964805 9.0 IC50 1.0 Preclinical
CHEMBL3985608 9.0 IC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
3
6.0
1
6.5
7
7.0
2
7.5
11
8.0
0
8.5
11
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PLERIXAFOR
CHEMBL18442
Approved 2008
Properties Compare Identifier
Assay Landscape

Assay Landscape

6
Total Assays
34
Tested Compounds
2
Assay Types
Functional — 3 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 1 8.4
Binding — 3 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 4 7.1
organism-based format 1 30 8.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine