Sonic hedgehog protein · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q15465. Use UniProt Q15465 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q15465 as the stable identity anchor, then attach disease evidence before program review.
Sonic hedgehog protein
Review this target as Sonic hedgehog protein, mapped to UniProt Q15465. Sequence length is 462 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sonic hedgehog protein as ChEMBL target CHEMBL5602, mapped to UniProt Q15465. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Sonic hedgehog protein is the right protein anchor across sources, using UniProt Q15465 as the stable mapping.
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| Preferred Name | Sonic hedgehog protein |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q15465 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sonic hedgehog protein |
| UniProt Accession | Q15465 |
| Component Type | Protein |
| Sequence Length | 462 aa |
Sonic hedgehog protein
Review this target as Sonic hedgehog protein, mapped to UniProt Q15465. Sequence length is 462 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL473417 | 7.82 | IC50 | 15.0 | Approved |
| CHEMBL480889 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL5276737 | 6.77 | Kd | 170.0 | Preclinical |
| CHEMBL186779 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL5185285 | 6.26 | Kd | 550.0 | Preclinical |
| CHEMBL1081556 | 6.24 | Kd | 570.0 | Preclinical |
| CHEMBL254129 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL1088172 | 5.75 | Kd | 1800.0 | Preclinical |
| CHEMBL1081726 | 5.51 | Kd | 3100.0 | Preclinical |
| CHEMBL473392 | 5.51 | Kd | 3100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 18 | 5.4 |
| cell-based format | 8 | 3 | 6.7 |
| assay format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 0 | — |