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Target Snapshot

CHEMBL5604 Target Snapshot

Dual specificity testis-specific protein kinase 1 · SINGLE PROTEIN · Homo sapiens

488Compounds
103Assays
5Approved Drugs
360.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q15569. Use UniProt Q15569 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q15569 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Dual specificity testis-specific protein kinase 1 as ChEMBL target CHEMBL5604, mapped to UniProt Q15569. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Dual specificity testis-specific protein kinase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5604
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q15569
Dual specificity testis-specific protein kinase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Dual specificity testis-specific protein kinase 1 is the right protein anchor across sources, using UniProt Q15569 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDual specificity testis-specific protein kinase 1
UniProt AccessionQ15569
Component TypeProtein
Sequence Length626 aa

Dual specificity testis-specific protein kinase 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Dual specificity testis-specific protein kinase 1, mapped to UniProt Q15569. Sequence length is 626 aa.

Mapped IDQ15569
Review nameDual specificity testis-specific protein kinase 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
2
Phase III
5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5030.0
KD330.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3752910 10.07 Kd 0.086 Preclinical
CHEMBL5416410 7.48 Kd 33.0 Approved
CHEMBL386051 7.1 Kd 79.0 Preclinical
CHEMBL388978 6.86 IC50 138.0 Preclinical
CHEMBL1230609 6.58 Kd 260.0 Clinical
CHEMBL3039525 6.54 Kd 286.0 Clinical
CHEMBL603469 6.54 Kd 290.0 Clinical
CHEMBL1241674 6.52 Kd 300.0 Preclinical
CHEMBL388978 6.5 Kd 320.0 Preclinical
CHEMBL475251 6.44 Kd 360.0 Clinical
Distribution

pChEMBL Value Distribution

5
5.0
12
5.5
4
6.0
10
6.5
4
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CRIZOTINIB
CHEMBL601719
Approved 2011
DASATINIB
CHEMBL5416410
Approved 2006
Assay Landscape

Assay Landscape

103
Total Assays
27
Tested Compounds
1
Assay Types
Binding — 103 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 82 24 6.2
assay format 19 0
cell-based format 1 0
subcellular format 1 3 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine