Use UniProt Q15569 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL5604 Target Snapshot
Dual specificity testis-specific protein kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q15569. Use UniProt Q15569 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity testis-specific protein kinase 1
Review this target as Dual specificity testis-specific protein kinase 1, mapped to UniProt Q15569. Sequence length is 626 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Dual specificity testis-specific protein kinase 1 as ChEMBL target CHEMBL5604, mapped to UniProt Q15569. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Dual specificity testis-specific protein kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q15569 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity testis-specific protein kinase 1 |
| UniProt Accession | Q15569 |
| Component Type | Protein |
| Sequence Length | 626 aa |
Dual specificity testis-specific protein kinase 1
How to read this target
Review this target as Dual specificity testis-specific protein kinase 1, mapped to UniProt Q15569. Sequence length is 626 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3752910 | 10.07 | Kd | 0.086 | Preclinical |
| CHEMBL5416410 | 7.48 | Kd | 33.0 | Approved |
| CHEMBL386051 | 7.1 | Kd | 79.0 | Preclinical |
| CHEMBL388978 | 6.86 | IC50 | 138.0 | Preclinical |
| CHEMBL1230609 | 6.58 | Kd | 260.0 | Clinical |
| CHEMBL3039525 | 6.54 | Kd | 286.0 | Clinical |
| CHEMBL603469 | 6.54 | Kd | 290.0 | Clinical |
| CHEMBL1241674 | 6.52 | Kd | 300.0 | Preclinical |
| CHEMBL388978 | 6.5 | Kd | 320.0 | Preclinical |
| CHEMBL475251 | 6.44 | Kd | 360.0 | Clinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 103 assays, 27 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 82 | 24 | 6.2 |
| assay format | 19 | 0 | — |
| cell-based format | 1 | 0 | — |
| subcellular format | 1 | 3 | 6.5 |