Serine/threonine-protein kinase Nek11 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8NG66. Use UniProt Q8NG66 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8NG66 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase Nek11
Review this target as Serine/threonine-protein kinase Nek11, mapped to UniProt Q8NG66. Sequence length is 645 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase Nek11 as ChEMBL target CHEMBL5638, mapped to UniProt Q8NG66. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Serine/threonine-protein kinase Nek11 is the right protein anchor across sources, using UniProt Q8NG66 as the stable mapping.
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| Preferred Name | Serine/threonine-protein kinase Nek11 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8NG66 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase Nek11 |
| UniProt Accession | Q8NG66 |
| Component Type | Protein |
| Sequence Length | 645 aa |
Serine/threonine-protein kinase Nek11
Review this target as Serine/threonine-protein kinase Nek11, mapped to UniProt Q8NG66. Sequence length is 645 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL475251 | 6.77 | Kd | 170.0 | Clinical |
| CHEMBL1229517 | 6.72 | Kd | 190.0 | Approved |
| CHEMBL1230020 | 6.72 | Kd | 190.0 | Preclinical |
| CHEMBL388978 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL5416410 | 6.33 | Kd | 470.0 | Approved |
| CHEMBL288441 | 6.19 | Kd | 650.0 | Approved |
| CHEMBL4088216 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL4097778 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL4549667 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL1908396 | 5.96 | Kd | 1100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 113 | 12 | 6.2 |
| assay format | 16 | 0 | — |
| cell-based format | 9 | 0 | — |