Serine/threonine-protein kinase WNK2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y3S1. Use UniProt Q9Y3S1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y3S1 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase WNK2
Review this target as Serine/threonine-protein kinase WNK2, mapped to UniProt Q9Y3S1. Sequence length is 2297 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase WNK2 as ChEMBL target CHEMBL5639, mapped to UniProt Q9Y3S1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase WNK2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y3S1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase WNK2 |
| UniProt Accession | Q9Y3S1 |
| Component Type | Protein |
| Sequence Length | 2297 aa |
Serine/threonine-protein kinase WNK2
Review this target as Serine/threonine-protein kinase WNK2, mapped to UniProt Q9Y3S1. Sequence length is 2297 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 6.03 | IC50 | 934.0 | Preclinical |
| CHEMBL3702566 | 5.55 | IC50 | 2785.0 | Preclinical |
| CHEMBL2171124 | 5.41 | IC50 | 3892.0 | Preclinical |
| CHEMBL3683258 | 5.09 | IC50 | 8086.0 | Preclinical |
| CHEMBL4848254 | 5.0 | Kd | 10000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 122 | 4 | 5.6 |
| cell-based format | 25 | 0 | — |
| assay format | 16 | 1 | 5.0 |
| subcellular format | 14 | 0 | — |