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Target Snapshot

CHEMBL5662 Target Snapshot

Salicyl-AMP ligase / salicyl-S-ArCP synthetase · SINGLE PROTEIN · Mycobacterium tuberculosis

112Compounds
14Assays
0Approved Drugs
123.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P71716. Use UniProt P71716 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P71716 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Salicyl-AMP ligase / salicyl-S-ArCP synthetase as ChEMBL target CHEMBL5662, mapped to UniProt P71716. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Salicyl-AMP ligase / salicyl-S-ArCP synthetase
SINGLE PROTEIN · Mycobacterium tuberculosis
As of 2026-09-14
ChEMBL target ID
CHEMBL5662
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P71716
Salicyl-AMP ligase / salicyl-S-ArCP synthetase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Salicyl-AMP ligase / salicyl-S-ArCP synthetase is the right protein anchor across sources, using UniProt P71716 as the stable mapping.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSalicyl-AMP ligase / salicyl-S-ArCP synthetase
UniProt AccessionP71716
Component TypeProtein
Sequence Length565 aa

Salicyl-AMP ligase / salicyl-S-ArCP synthetase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Salicyl-AMP ligase / salicyl-S-ArCP synthetase, mapped to UniProt P71716. Sequence length is 565 aa.

Mapped IDP71716
Review nameSalicyl-AMP ligase / salicyl-S-ArCP synthetase
OrganismMycobacterium tuberculosis
Assay Mix

Activity Type Distribution

IC501.0
KI121.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL608841 9.57 Ki 0.27 Preclinical
CHEMBL611772 9.54 Ki 0.29 Preclinical
CHEMBL611766 9.49 Ki 0.32 Preclinical
CHEMBL611777 9.4 Ki 0.4 Preclinical
CHEMBL612049 9.39 Ki 0.41 Preclinical
CHEMBL612048 9.34 Ki 0.46 Preclinical
CHEMBL611785 9.32 Ki 0.48 Preclinical
CHEMBL609105 9.27 Ki 0.54 Preclinical
CHEMBL612052 9.24 Ki 0.57 Preclinical
CHEMBL608839 9.23 Ki 0.59 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
7
5.5
8
6.0
4
6.5
8
7.0
12
7.5
19
8.0
19
8.5
21
9.0
2
9.5
pChEMBL
Assay Landscape

Assay Landscape

14
Total Assays
104
Tested Compounds
1
Assay Types
Binding — 14 assays, 104 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 11 7.7
assay format 5 93 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine