G protein-coupled receptor kinase 5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P34947. Use UniProt P34947 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P34947 as the stable identity anchor, then attach disease evidence before program review.
G protein-coupled receptor kinase 5
Review this target as G protein-coupled receptor kinase 5, mapped to UniProt P34947. Sequence length is 590 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats G protein-coupled receptor kinase 5 as ChEMBL target CHEMBL5678, mapped to UniProt P34947. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | G protein-coupled receptor kinase 5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P34947 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G protein-coupled receptor kinase 5 |
| UniProt Accession | P34947 |
| Component Type | Protein |
| Sequence Length | 590 aa |
G protein-coupled receptor kinase 5
Review this target as G protein-coupled receptor kinase 5, mapped to UniProt P34947. Sequence length is 590 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4786599 | 8.42 | IC50 | 3.8 | Preclinical |
| CHEMBL4785430 | 8.07 | IC50 | 8.6 | Preclinical |
| CHEMBL5569207 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4877302 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL4780266 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4800665 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4786599 | 7.72 | Ki | 19.0 | Preclinical |
| CHEMBL5415336 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL4782014 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL388978 | 7.61 | IC50 | 24.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 142 | 154 | 5.5 |
| assay format | 15 | 43 | 6.7 |
| cell-based format | 9 | 6 | 5.2 |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 113 | 5.5 |