Muscle, skeletal receptor tyrosine-protein kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O15146. Use UniProt O15146 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15146 as the stable identity anchor, then attach disease evidence before program review.
Muscle, skeletal receptor tyrosine-protein kinase
Review this target as Muscle, skeletal receptor tyrosine-protein kinase, mapped to UniProt O15146. Sequence length is 869 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscle, skeletal receptor tyrosine-protein kinase as ChEMBL target CHEMBL5684, mapped to UniProt O15146. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscle, skeletal receptor tyrosine-protein kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15146 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscle, skeletal receptor tyrosine-protein kinase |
| UniProt Accession | O15146 |
| Component Type | Protein |
| Sequence Length | 869 aa |
Muscle, skeletal receptor tyrosine-protein kinase
Review this target as Muscle, skeletal receptor tyrosine-protein kinase, mapped to UniProt O15146. Sequence length is 869 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL574738 | 8.51 | Kd | 3.1 | Preclinical |
| CHEMBL388978 | 8.42 | IC50 | 3.8 | Preclinical |
| CHEMBL601719 | 8.04 | IC50 | 9.1 | Approved |
| CHEMBL223360 | 8.0 | Kd | 10.0 | Clinical |
| CHEMBL5423601 | 7.89 | IC50 | 12.83 | Preclinical |
| CHEMBL1230609 | 7.89 | Kd | 13.0 | Clinical |
| CHEMBL4212531 | 7.28 | IC50 | 53.0 | Preclinical |
| CHEMBL388978 | 7.07 | Kd | 86.0 | Preclinical |
| CHEMBL1721885 | 7.0 | Kd | 100.0 | Clinical |
| CHEMBL475251 | 7.0 | Kd | 100.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 201 | 30 | 6.6 |
| assay format | 32 | 4 | 7.0 |
| cell-based format | 8 | 0 | — |