Tryptophan 5-hydroxylase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Tryptophan 5-hydroxylase 1 shows clinical signal disease relevance led by pulmonary arterial hypertension. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P17752. Start with pulmonary arterial hypertension, then reuse UniProt P17752 as the stable protein anchor across project notes and exports.
Start with pulmonary arterial hypertension, then reuse UniProt P17752 as the stable protein anchor across project notes and exports.
Tryptophan 5-hydroxylase 1 shows clinical signal disease relevance led by pulmonary arterial hypertension. 1 linked drug remains visible in the same block.
Start review with pulmonary arterial hypertension because it currently carries clinical signal support. Linked drugs include RODATRISTAT ETHYL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTryptophan 5-hydroxylase 1
Review this target as Tryptophan 5-hydroxylase 1, mapped to UniProt P17752. Sequence length is 444 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tryptophan 5-hydroxylase 1 as ChEMBL target CHEMBL5689, mapped to UniProt P17752. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Tryptophan 5-hydroxylase 1 is the right protein anchor across sources, using UniProt P17752 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why pulmonary arterial hypertension is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Tryptophan 5-hydroxylase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P17752 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tryptophan 5-hydroxylase 1 |
| UniProt Accession | P17752 |
| Component Type | Protein |
| Sequence Length | 444 aa |
Tryptophan 5-hydroxylase 1
Review this target as Tryptophan 5-hydroxylase 1, mapped to UniProt P17752. Sequence length is 444 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tryptophan 5-hydroxylase 1 shows clinical signal disease relevance led by pulmonary arterial hypertension.
Start review with pulmonary arterial hypertension because it currently carries clinical signal support. Linked drugs include RODATRISTAT ETHYL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5808085 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5818377 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5912323 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5918977 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5966948 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5973645 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL6044111 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5762081 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5764796 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5803526 | 8.52 | IC50 | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 16 | 263 | 6.7 |
| cell-based format | 5 | 443 | 7.7 |
| assay format | 3 | 88 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 69 | 6.6 |