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Evidence Snapshot

NUAK family SNF1-like kinase 2

CHEMBL5698 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5698
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NUAK family SNF1-like kinase 2 as ChEMBL target CHEMBL5698, mapped to UniProt Q9H093. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NUAK family SNF1-like kinase 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5698
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9H093
NUAK family SNF1-like kinase 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why NUAK family SNF1-like kinase 2 matters

As of 2026-09-13

NUAK family SNF1-like kinase 2 is reviewed as NUAK family SNF1-like kinase 2 (UniProt Q9H093); the current evidence base includes 12 approved drugs, 563 compounds, and 196 assays, with lead potency reaching pChEMBL 10.1.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 12 approved drugs, 563 compounds, and 196 assays for this target. The dominant activity type is KD. CHEMBL388978 is the current potency anchor at pChEMBL 10.1.

Use CHEMBL388978 as the tractability anchor when discussing potency (pChEMBL 10.1).

Activity source · ChEMBL 36 via Core Engine
12 approved pChEMBL 10.1
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why NUAK family SNF1-like kinase 2 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9H093, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

563
Total Compounds
196
Total Assays
12
Approved Drugs
IC50: 20.0, EC50: 1.0, KD: 359.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL388978
 10.1 Kd —
No preferred name
CHEMBL3904602
 9.2 Kd Clinical
No preferred name
CHEMBL603469
 9.0 Kd Clinical
No preferred name
CHEMBL509032
 8.9 Kd —
No preferred name
CHEMBL388978
 8.8 IC50 —

Approved Drugs

Structure Compound First Approval
FEDRATINIB
CHEMBL1287853
 2019
MIDOSTAURIN
CHEMBL608533
 2017
NERATINIB
CHEMBL180022
 2017
NINTEDANIB
CHEMBL502835
 2014
BOSUTINIB
CHEMBL288441
 2012
TOFACITINIB CITRATE
CHEMBL2103743
 2012
TOFACITINIB
CHEMBL221959
 2012
CRIZOTINIB
CHEMBL601719
 2011
RUXOLITINIB
CHEMBL1789941
 2011
SUNITINIB
CHEMBL535
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5698