Serine/threonine-protein kinase SIK2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9H0K1. Use UniProt Q9H0K1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9H0K1 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase SIK2
Review this target as Serine/threonine-protein kinase SIK2, mapped to UniProt Q9H0K1. Sequence length is 926 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase SIK2 as ChEMBL target CHEMBL5699, mapped to UniProt Q9H0K1. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Serine/threonine-protein kinase SIK2 is the right protein anchor across sources, using UniProt Q9H0K1 as the stable mapping.
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| Preferred Name | Serine/threonine-protein kinase SIK2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9H0K1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase SIK2 |
| UniProt Accession | Q9H0K1 |
| Component Type | Protein |
| Sequence Length | 926 aa |
Serine/threonine-protein kinase SIK2
Review this target as Serine/threonine-protein kinase SIK2, mapped to UniProt Q9H0K1. Sequence length is 926 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5090394 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL388978 | 9.51 | IC50 | 0.306 | Preclinical |
| CHEMBL5407103 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5394880 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL4553284 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL5430450 | 9.21 | IC50 | 0.61 | Preclinical |
| CHEMBL1980995 | 9.2 | Ki | 0.631 | Preclinical |
| CHEMBL5426204 | 9.19 | IC50 | 0.64 | Preclinical |
| CHEMBL5417444 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL5416410 | 9.1 | Ki | 0.7943 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 194 | 132 | 7.2 |
| assay format | 27 | 2 | 7.6 |
| cell-based format | 19 | 61 | 6.6 |
| subcellular format | 10 | 40 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 20 | 7.0 |