Mitogen-activated protein kinase 8 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P49185. Use UniProt P49185 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49185 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 8
Review this target as Mitogen-activated protein kinase 8, mapped to UniProt P49185. Sequence length is 411 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase 8 as ChEMBL target CHEMBL5718, mapped to UniProt P49185. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase 8 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P49185 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 8 |
| UniProt Accession | P49185 |
| Component Type | Protein |
| Sequence Length | 411 aa |
Mitogen-activated protein kinase 8
Review this target as Mitogen-activated protein kinase 8, mapped to UniProt P49185. Sequence length is 411 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL259720 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL261413 | 6.48 | IC50 | 330.0 | Preclinical |
| CHEMBL411083 | 6.32 | IC50 | 480.0 | Preclinical |
| CHEMBL258845 | 6.17 | IC50 | 670.0 | Preclinical |
| CHEMBL258618 | 6.14 | IC50 | 720.0 | Preclinical |
| CHEMBL260064 | 6.14 | IC50 | 730.0 | Preclinical |
| CHEMBL260065 | 5.98 | IC50 | 1050.0 | Preclinical |
| CHEMBL409350 | 5.94 | IC50 | 1140.0 | Preclinical |
| CHEMBL437107 | 5.66 | IC50 | 2180.0 | Preclinical |
| CHEMBL259554 | 5.64 | IC50 | 2300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 11 | 6.1 |