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Target Snapshot

CHEMBL5724 Target Snapshot

Arylamine N-acetyltransferase 2 · SINGLE PROTEIN · Mus musculus

68Compounds
6Assays
0Approved Drugs
69.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P50295. Use UniProt P50295 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P50295 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Arylamine N-acetyltransferase 2 as ChEMBL target CHEMBL5724, mapped to UniProt P50295. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Arylamine N-acetyltransferase 2
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL5724
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P50295
Arylamine N-acetyltransferase 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Arylamine N-acetyltransferase 2 is the right protein anchor across sources, using UniProt P50295 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelArylamine N-acetyltransferase 2
UniProt AccessionP50295
Component TypeProtein
Sequence Length290 aa

Arylamine N-acetyltransferase 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Arylamine N-acetyltransferase 2, mapped to UniProt P50295. Sequence length is 290 aa.

Mapped IDP50295
Review nameArylamine N-acetyltransferase 2
OrganismMus musculus
Assay Mix

Activity Type Distribution

IC5069.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3262086 6.57 IC50 270.0 Preclinical
CHEMBL511164 6.52 IC50 300.0 Preclinical
CHEMBL3262085 6.37 IC50 430.0 Preclinical
CHEMBL458955 6.0 IC50 1000.0 Preclinical
CHEMBL3262055 5.96 IC50 1100.0 Preclinical
CHEMBL457446 5.89 IC50 1300.0 Preclinical
CHEMBL3262062 5.85 IC50 1400.0 Preclinical
CHEMBL3262049 5.77 IC50 1700.0 Preclinical
CHEMBL3262053 5.75 IC50 1800.0 Preclinical
CHEMBL1568345 5.72 IC50 1900.0 Preclinical
Distribution

pChEMBL Value Distribution

20
5.0
9
5.5
2
6.0
2
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

6
Total Assays
48
Tested Compounds
1
Assay Types
Binding — 6 assays, 48 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 22 5.4
single protein format 3 26 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine