Use UniProt P01256 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL5735 Target Snapshot
Calcitonin gene-related peptide 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P01256. Use UniProt P01256 as the stable identity anchor, then attach disease evidence before program review.
Calcitonin gene-related peptide 1
Review this target as Calcitonin gene-related peptide 1, mapped to UniProt P01256. Sequence length is 128 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Calcitonin gene-related peptide 1 as ChEMBL target CHEMBL5735, mapped to UniProt P01256. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Calcitonin gene-related peptide 1 is the right protein anchor across sources, using UniProt P01256 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | Calcitonin gene-related peptide 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P01256 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Calcitonin gene-related peptide 1 |
| UniProt Accession | P01256 |
| Component Type | Protein |
| Sequence Length | 128 aa |
Calcitonin gene-related peptide 1
How to read this target
Review this target as Calcitonin gene-related peptide 1, mapped to UniProt P01256. Sequence length is 128 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL509329 | 8.05 | IC50 | 8.9 | Preclinical |
| CHEMBL504769 | 7.69 | IC50 | 20.4 | Preclinical |
| CHEMBL236593 | 5.92 | Ki | 1200.0 | Clinical |
| CHEMBL1910947 | 5.17 | Ki | 6800.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 1 assays, 2 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 2 | 5.5 |
Functional — 1 assays, 2 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 2 | 7.9 |