ATP-binding cassette sub-family C member 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q92887. Use UniProt Q92887 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q92887 as the stable identity anchor, then attach disease evidence before program review.
ATP-binding cassette sub-family C member 2
Review this target as ATP-binding cassette sub-family C member 2, mapped to UniProt Q92887. Sequence length is 1545 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ATP-binding cassette sub-family C member 2 as ChEMBL target CHEMBL5748, mapped to UniProt Q92887. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | ATP-binding cassette sub-family C member 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q92887 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | ATP-binding cassette sub-family C member 2 |
| UniProt Accession | Q92887 |
| Component Type | Protein |
| Sequence Length | 1545 aa |
ATP-binding cassette sub-family C member 2
Review this target as ATP-binding cassette sub-family C member 2, mapped to UniProt Q92887. Sequence length is 1545 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2074720 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL3038248 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL1829174 | 5.62 | IC50 | 2410.0 | Clinical |
| CHEMBL160 | 5.51 | IC50 | 3100.0 | Approved |
| CHEMBL495936 | 5.48 | IC50 | 3300.0 | Preclinical |
| CHEMBL2074650 | 5.43 | Ki | 3700.0 | Preclinical |
| CHEMBL456 | 5.42 | IC50 | 3850.0 | Approved |
| CHEMBL15177 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL3974624 | 5.39 | IC50 | 4100.0 | Preclinical |
| CHEMBL3263914 | 5.35 | IC50 | 4500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 47 | 11 | 5.1 |
| cell membrane format | 28 | 7 | 4.9 |
| organism-based format | 2 | 0 | — |
| subcellular format | 2 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 22 | 27 | 4.5 |
| single protein format | 9 | 3 | 5.2 |
| assay format | 5 | 2 | 4.2 |
| cell membrane format | 3 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 25 | 5.0 |
| single protein format | 13 | 8 | 4.4 |
| assay format | 1 | 2 | 5.2 |