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Target Snapshot

CHEMBL5755 Target Snapshot

Adenylate cyclase · SINGLE PROTEIN · Arthrospira platensis

6Compounds
1Assays
1Approved Drugs
6.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O32393. Use UniProt O32393 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O32393 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adenylate cyclase as ChEMBL target CHEMBL5755, mapped to UniProt O32393. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adenylate cyclase
SINGLE PROTEIN · Arthrospira platensis
As of 2026-09-14
ChEMBL target ID
CHEMBL5755
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O32393
histidine kinase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adenylate cyclase is the right protein anchor across sources, using UniProt O32393 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labelhistidine kinase
UniProt AccessionO32393
Component TypeProtein
Sequence Length1202 aa

histidine kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Adenylate cyclase, mapped to UniProt O32393. ChEMBL maps the protein component as histidine kinase. Sequence length is 1202 aa.

Mapped IDO32393
Review nameAdenylate cyclase
OrganismArthrospira platensis
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC506.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL401844 5.3 IC50 5000.0 Preclinical
CHEMBL387152 4.82 IC50 15000.0 Preclinical
CHEMBL442 4.16 IC50 70000.0 Approved
CHEMBL469203 4.0 IC50 100000.0 Preclinical
CHEMBL481854 4.0 IC50 100000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 1 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 6 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine