Mitogen-activated protein kinase 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P31152. Use UniProt P31152 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31152 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 4
Review this target as Mitogen-activated protein kinase 4, mapped to UniProt P31152. Sequence length is 587 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase 4 as ChEMBL target CHEMBL5759, mapped to UniProt P31152. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P31152 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 4 |
| UniProt Accession | P31152 |
| Component Type | Protein |
| Sequence Length | 587 aa |
Mitogen-activated protein kinase 4
Review this target as Mitogen-activated protein kinase 4, mapped to UniProt P31152. Sequence length is 587 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4088216 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL4549667 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL386051 | 5.96 | Kd | 1100.0 | Preclinical |
| CHEMBL191003 | 5.8 | Kd | 1600.0 | Preclinical |
| CHEMBL553 | 5.6 | Kd | 2500.0 | Approved |
| CHEMBL939 | 5.51 | Kd | 3100.0 | Approved |
| CHEMBL296468 | 5.39 | Kd | 4100.0 | Preclinical |
| CHEMBL31965 | 5.27 | Kd | 5400.0 | Clinical |
| CHEMBL4445812 | 5.27 | Kd | 5320.0 | Preclinical |
| CHEMBL2425628 | 4.96 | Kd | 11000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 56 | 10 | 5.5 |
| assay format | 17 | 1 | 5.3 |
| subcellular format | 4 | 0 | — |
| cell-based format | 1 | 0 | — |