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Target Snapshot

CHEMBL5767 Target Snapshot

PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) · SINGLE PROTEIN · Mycobacterium tuberculosis

101Compounds
7Assays
11Approved Drugs
107.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P96878. Use UniProt P96878 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P96878 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) as ChEMBL target CHEMBL5767, mapped to UniProt P96878. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)
SINGLE PROTEIN · Mycobacterium tuberculosis
As of 2026-09-14
ChEMBL target ID
CHEMBL5767
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P96878
carbonic anhydrase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) is the right protein anchor across sources, using UniProt P96878 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labelcarbonic anhydrase
UniProt AccessionP96878
Component TypeProtein
Sequence Length764 aa

carbonic anhydrase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE), mapped to UniProt P96878. ChEMBL maps the protein component as carbonic anhydrase. Sequence length is 764 aa.

Mapped IDP96878
Review namePROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)
OrganismMycobacterium tuberculosis
Clinical Profile

Clinical Phase Distribution

11
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

KI107.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL501294 9.03 Ki 0.93 Preclinical
CHEMBL1614844 8.19 Ki 6.5 Preclinical
CHEMBL316779 8.19 Ki 6.4 Preclinical
CHEMBL512633 8.14 Ki 7.2 Preclinical
CHEMBL20 7.92 Ki 12.0 Approved
CHEMBL77517 7.82 Ki 15.0 Clinical
CHEMBL6633 7.48 Ki 33.0 Preclinical
CHEMBL467897 7.42 Ki 38.0 Preclinical
CHEMBL6724 7.4 Ki 40.0 Preclinical
CHEMBL1615281 7.28 Ki 53.0 Preclinical
Distribution

pChEMBL Value Distribution

23
5.0
5
5.5
22
6.0
15
6.5
23
7.0
2
7.5
3
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZONISAMIDE
CHEMBL750
Approved 2000
BRINZOLAMIDE
CHEMBL220491
Approved 1998
DORZOLAMIDE
CHEMBL218490
Approved 1994
METHAZOLAMIDE
CHEMBL19
Approved 1959
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

7
Total Assays
101
Tested Compounds
1
Assay Types
Binding — 7 assays, 101 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 101 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine