Monoglyceride lipase · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt O35678. Use UniProt O35678 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O35678 as the stable identity anchor, then attach disease evidence before program review.
Monoglyceride lipase
Review this target as Monoglyceride lipase, mapped to UniProt O35678. Sequence length is 303 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Monoglyceride lipase as ChEMBL target CHEMBL5774, mapped to UniProt O35678. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Monoglyceride lipase |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O35678 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Monoglyceride lipase |
| UniProt Accession | O35678 |
| Component Type | Protein |
| Sequence Length | 303 aa |
Monoglyceride lipase
Review this target as Monoglyceride lipase, mapped to UniProt O35678. Sequence length is 303 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5569248 | 10.59 | IC50 | 0.026 | Preclinical |
| CHEMBL5575673 | 10.31 | IC50 | 0.049 | Preclinical |
| CHEMBL3787346 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL462582 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL6067709 | 10.09 | IC50 | 0.081 | Preclinical |
| CHEMBL3785379 | 9.98 | IC50 | 0.105 | Preclinical |
| CHEMBL462610 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL4203881 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL4216513 | 9.72 | IC50 | 0.191 | Preclinical |
| CHEMBL1232635 | 9.66 | IC50 | 0.219 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 27 | 59 | 6.5 |
| single protein format | 14 | 57 | 7.8 |
| tissue-based format | 12 | 27 | 7.8 |
| assay format | 8 | 127 | 6.2 |
| cell-based format | 6 | 10 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 15 | 0 | — |
| tissue-based format | 1 | 1 | 9.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 5.2 |