Toll-like receptor 8 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Toll-like receptor 8 shows clinical signal disease relevance led by dermatomyositis. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9NR97. Start with dermatomyositis, then reuse UniProt Q9NR97 as the stable protein anchor across project notes and exports.
Start with dermatomyositis, then reuse UniProt Q9NR97 as the stable protein anchor across project notes and exports.
Toll-like receptor 8 shows clinical signal disease relevance led by dermatomyositis. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with dermatomyositis because it currently carries clinical signal support. Linked drugs include BAZLITORAN, ENPATORAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyToll-like receptor 8
Review this target as Toll-like receptor 8, mapped to UniProt Q9NR97. Sequence length is 1041 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Toll-like receptor 8 as ChEMBL target CHEMBL5805, mapped to UniProt Q9NR97. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Toll-like receptor 8 is the right protein anchor across sources, using UniProt Q9NR97 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why dermatomyositis is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Toll-like receptor 8 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NR97 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Toll-like receptor 8 |
| UniProt Accession | Q9NR97 |
| Component Type | Protein |
| Sequence Length | 1041 aa |
Toll-like receptor 8
Review this target as Toll-like receptor 8, mapped to UniProt Q9NR97. Sequence length is 1041 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Toll-like receptor 8 shows clinical signal disease relevance led by dermatomyositis. 5 more disease programs remain visible in the same review block.
Start review with dermatomyositis because it currently carries clinical signal support. Linked drugs include BAZLITORAN, ENPATORAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5078689 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL5277999 | 10.3 | EC50 | 0.05 | Preclinical |
| CHEMBL5090067 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL5091113 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL5291249 | 10.1 | EC50 | 0.08 | Preclinical |
| CHEMBL5399590 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5273537 | 9.96 | EC50 | 0.11 | Preclinical |
| CHEMBL5745669 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL5823006 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL5760762 | 9.82 | IC50 | 0.15 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 168 | 495 | 6.3 |
| single protein format | 83 | 38 | 6.8 |
| assay format | 24 | 3,539 | 8.0 |
| tissue-based format | 18 | 28 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 24 | 5.4 |
| assay format | 7 | 1 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |