Cyclin-dependent kinase 11B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P21127. Use UniProt P21127 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P21127 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-dependent kinase 11B
Review this target as Cyclin-dependent kinase 11B, mapped to UniProt P21127. Sequence length is 795 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclin-dependent kinase 11B as ChEMBL target CHEMBL5808, mapped to UniProt P21127. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclin-dependent kinase 11B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P21127 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-dependent kinase 11B |
| UniProt Accession | P21127 |
| Component Type | Protein |
| Sequence Length | 795 aa |
Cyclin-dependent kinase 11B
Review this target as Cyclin-dependent kinase 11B, mapped to UniProt P21127. Sequence length is 795 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL445813 | 8.08 | Kd | 8.4 | Clinical |
| CHEMBL1232461 | 7.7 | IC50 | 20.0 | Clinical |
| CHEMBL2148124 | 7.5 | Kd | 32.0 | Preclinical |
| CHEMBL1232461 | 7.47 | Kd | 34.0 | Clinical |
| CHEMBL4101411 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL296468 | 7.01 | Kd | 98.0 | Preclinical |
| CHEMBL191003 | 6.82 | Kd | 150.0 | Preclinical |
| CHEMBL572878 | 6.54 | Kd | 290.0 | Clinical |
| CHEMBL4553037 | 6.43 | Kd | 370.0 | Preclinical |
| CHEMBL249697 | 6.38 | Kd | 420.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 82 | 19 | 6.4 |
| assay format | 25 | 1 | 6.4 |
| cell-based format | 16 | 0 | — |
| subcellular format | 8 | 0 | — |