Receptor tyrosine-protein kinase erbB-3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Receptor tyrosine-protein kinase erbB-3 shows late clinical disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 8 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P21860. Start with neoplasm, then reuse UniProt P21860 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P21860 as the stable protein anchor across project notes and exports.
Receptor tyrosine-protein kinase erbB-3 shows late clinical disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 8 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries late clinical support. Linked drugs include AMG-888, AV-203, DULIGOTUZUMAB, LUMRETUZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyReceptor tyrosine-protein kinase erbB-3
Review this target as Receptor tyrosine-protein kinase erbB-3, mapped to UniProt P21860. Sequence length is 1342 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Receptor tyrosine-protein kinase erbB-3 as ChEMBL target CHEMBL5838, mapped to UniProt P21860. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Receptor tyrosine-protein kinase erbB-3 is the right protein anchor across sources, using UniProt P21860 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as late clinical support. It currently carries 8 linked drugs in the same disease frame.
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| Preferred Name | Receptor tyrosine-protein kinase erbB-3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P21860 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Receptor tyrosine-protein kinase erbB-3 |
| UniProt Accession | P21860 |
| Component Type | Protein |
| Sequence Length | 1342 aa |
Receptor tyrosine-protein kinase erbB-3
Review this target as Receptor tyrosine-protein kinase erbB-3, mapped to UniProt P21860. Sequence length is 1342 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Receptor tyrosine-protein kinase erbB-3 shows late clinical disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries late clinical support. Linked drugs include AMG-888, AV-203, DULIGOTUZUMAB, LUMRETUZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL288441 | 9.11 | Kd | 0.77 | Approved |
| CHEMBL3883534 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4228518 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL4225777 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL4226676 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL3608429 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4216679 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4226151 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3353410 | 8.68 | IC50 | 2.1 | Approved |
| CHEMBL4225565 | 8.62 | IC50 | 2.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 57 | 42 | 6.4 |
| assay format | 20 | 23 | 6.7 |
| cell-based format | 18 | 12 | 8.1 |