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Target Snapshot

CHEMBL5849 Target Snapshot

Mas-related G-protein coupled receptor member X2 · SINGLE PROTEIN · Homo sapiens

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138Compounds
44Assays
9Approved Drugs
134.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q96LB1. Use UniProt Q96LB1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96LB1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mas-related G-protein coupled receptor member X2 as ChEMBL target CHEMBL5849, mapped to UniProt Q96LB1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mas-related G-protein coupled receptor member X2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5849
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q96LB1
Mas-related G-protein coupled receptor member X2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mas-related G-protein coupled receptor member X2 is the right protein anchor across sources, using UniProt Q96LB1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMas-related G-protein coupled receptor member X2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ96LB1
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMas-related G-protein coupled receptor member X2
UniProt AccessionQ96LB1
Component TypeProtein
Sequence Length330 aa

Mas-related G-protein coupled receptor member X2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Mas-related G-protein coupled receptor member X2, mapped to UniProt Q96LB1. Sequence length is 330 aa.

Mapped IDQ96LB1
Review nameMas-related G-protein coupled receptor member X2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

9
Approved
1
Phase III
4
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC506.0
EC50128.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5184300 8.6 IC50 2.512 Preclinical
CHEMBL5665416 6.86 EC50 138.04 Preclinical
CHEMBL5192321 6.84 EC50 144.54 Preclinical
CHEMBL503688 6.8 EC50 158.49 Preclinical
CHEMBL327745 6.54 EC50 288.4 Preclinical
CHEMBL5184932 6.54 EC50 290.0 Preclinical
CHEMBL463274 6.5 EC50 316.23 Preclinical
CHEMBL5665419 6.42 EC50 380.0 Preclinical
CHEMBL502480 6.4 EC50 398.11 Preclinical
CHEMBL2448526 6.3 EC50 501.19 Preclinical
Distribution

pChEMBL Value Distribution

25
5.0
11
5.5
18
6.0
7
6.5
0
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CETRORELIX
CHEMBL1200490
Approved 1999
Properties Compare Identifier
Assay Landscape

Assay Landscape

44
Total Assays
54
Tested Compounds
2
Assay Types
Functional — 29 assays, 54 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 27 47 5.2
assay format 2 7 6.3
Binding — 15 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 12 3 6.1
cell-based format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine