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Target Snapshot

CHEMBL5854 Target Snapshot

Adenylate cyclase type 10 · SINGLE PROTEIN · Homo sapiens

60Compounds
14Assays
0Approved Drugs
83.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q96PN6. Use UniProt Q96PN6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96PN6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adenylate cyclase type 10 as ChEMBL target CHEMBL5854, mapped to UniProt Q96PN6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adenylate cyclase type 10
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5854
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q96PN6
Adenylate cyclase type 10
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adenylate cyclase type 10 is the right protein anchor across sources, using UniProt Q96PN6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAdenylate cyclase type 10
UniProt AccessionQ96PN6
Component TypeProtein
Sequence Length1610 aa

Adenylate cyclase type 10

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Adenylate cyclase type 10, mapped to UniProt Q96PN6. Sequence length is 1610 aa.

Mapped IDQ96PN6
Review nameAdenylate cyclase type 10
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5071.0
KD12.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5220685 9.0 IC50 1.0 Preclinical
CHEMBL5219579 8.96 Kd 1.1 Preclinical
CHEMBL5219830 8.85 Kd 1.4 Preclinical
CHEMBL5220685 8.77 Kd 1.7 Preclinical
CHEMBL5218615 8.68 Kd 2.1 Preclinical
CHEMBL5218878 8.68 IC50 2.1 Preclinical
CHEMBL5218552 8.66 IC50 2.2 Preclinical
CHEMBL5220647 8.64 Kd 2.3 Preclinical
CHEMBL5218615 8.62 IC50 2.4 Preclinical
CHEMBL5218552 8.6 Kd 2.5 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
8
5.5
14
6.0
12
6.5
5
7.0
5
7.5
13
8.0
9
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

14
Total Assays
56
Tested Compounds
1
Assay Types
Binding — 14 assays, 56 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 12 49 7.2
assay format 1 3 5.2
cell-based format 1 4 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine