RAC-alpha serine/threonine-protein kinase · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P31750. Use UniProt P31750 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31750 as the stable identity anchor, then attach disease evidence before program review.
RAC-alpha serine/threonine-protein kinase
Review this target as RAC-alpha serine/threonine-protein kinase, mapped to UniProt P31750. Sequence length is 480 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats RAC-alpha serine/threonine-protein kinase as ChEMBL target CHEMBL5859, mapped to UniProt P31750. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | RAC-alpha serine/threonine-protein kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P31750 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | RAC-alpha serine/threonine-protein kinase |
| UniProt Accession | P31750 |
| Component Type | Protein |
| Sequence Length | 480 aa |
RAC-alpha serine/threonine-protein kinase
Review this target as RAC-alpha serine/threonine-protein kinase, mapped to UniProt P31750. Sequence length is 480 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL575448 | 7.66 | IC50 | 22.0 | Clinical |
| CHEMBL1685065 | 6.3 | Ki | 500.0 | Preclinical |
| CHEMBL1685066 | 5.8 | Ki | 1600.0 | Preclinical |
| CHEMBL595583 | 5.62 | Ki | 2400.0 | Preclinical |
| CHEMBL1685055 | 5.37 | Ki | 4300.0 | Preclinical |
| CHEMBL1681823 | 5.3 | Ki | 5000.0 | Preclinical |
| CHEMBL1685049 | 5.25 | Ki | 5600.0 | Preclinical |
| CHEMBL1685058 | 5.22 | Ki | 6000.0 | Preclinical |
| CHEMBL1685053 | 5.16 | Ki | 7000.0 | Preclinical |
| CHEMBL1685050 | 5.12 | Ki | 7600.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 58 | 1 | 7.7 |
| single protein format | 8 | 26 | 5.1 |
| assay format | 6 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |