G protein-coupled receptor kinase 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P32298. Use UniProt P32298 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P32298 as the stable identity anchor, then attach disease evidence before program review.
G protein-coupled receptor kinase 4
Review this target as G protein-coupled receptor kinase 4, mapped to UniProt P32298. Sequence length is 578 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats G protein-coupled receptor kinase 4 as ChEMBL target CHEMBL5861, mapped to UniProt P32298. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | G protein-coupled receptor kinase 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P32298 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G protein-coupled receptor kinase 4 |
| UniProt Accession | P32298 |
| Component Type | Protein |
| Sequence Length | 578 aa |
G protein-coupled receptor kinase 4
Review this target as G protein-coupled receptor kinase 4, mapped to UniProt P32298. Sequence length is 578 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL603469 | 7.92 | Kd | 12.0 | Clinical |
| CHEMBL502835 | 7.77 | Kd | 17.0 | Approved |
| CHEMBL4877302 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL388978 | 7.43 | Kd | 37.0 | Preclinical |
| CHEMBL388978 | 7.16 | IC50 | 69.9 | Preclinical |
| CHEMBL1908397 | 7.15 | Kd | 71.0 | Preclinical |
| CHEMBL4854871 | 7.01 | IC50 | 97.0 | Preclinical |
| CHEMBL522892 | 7.01 | Kd | 97.0 | Clinical |
| CHEMBL608533 | 6.96 | Kd | 110.0 | Approved |
| CHEMBL535 | 6.85 | Kd | 140.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 108 | 31 | 6.5 |
| assay format | 29 | 6 | 5.4 |
| cell-based format | 2 | 0 | — |