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Target Snapshot

CHEMBL5865 Target Snapshot

Transcriptional activator protein TraR · SINGLE PROTEIN · Agrobacterium tumefaciens

92Compounds
11Assays
0Approved Drugs
74.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P33905. Use UniProt P33905 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P33905 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Transcriptional activator protein TraR as ChEMBL target CHEMBL5865, mapped to UniProt P33905. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Transcriptional activator protein TraR
SINGLE PROTEIN · Agrobacterium tumefaciens
As of 2026-09-14
ChEMBL target ID
CHEMBL5865
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P33905
Transcriptional activator protein TraR
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Transcriptional activator protein TraR is the right protein anchor across sources, using UniProt P33905 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTranscriptional activator protein TraR
UniProt AccessionP33905
Component TypeProtein
Sequence Length234 aa

Transcriptional activator protein TraR

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Transcriptional activator protein TraR, mapped to UniProt P33905. Sequence length is 234 aa.

Mapped IDP33905
Review nameTranscriptional activator protein TraR
OrganismAgrobacterium tumefaciens
Assay Mix

Activity Type Distribution

IC5062.0
EC5012.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL584972 6.89 IC50 130.0 Preclinical
CHEMBL405298 6.7 EC50 200.0 Preclinical
CHEMBL467396 6.68 IC50 210.0 Preclinical
CHEMBL575294 6.6 IC50 250.0 Preclinical
CHEMBL501141 6.54 IC50 290.0 Preclinical
CHEMBL502443 6.36 IC50 440.0 Preclinical
CHEMBL503197 6.34 IC50 460.0 Preclinical
CHEMBL473592 6.3 IC50 500.0 Preclinical
CHEMBL512914 6.29 IC50 510.0 Preclinical
CHEMBL5596455 6.22 IC50 600.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
16
5.5
15
6.0
5
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

11
Total Assays
32
Tested Compounds
2
Assay Types
Functional — 9 assays, 32 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 9 32 5.8
Binding — 2 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 7 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine