Nuclear receptor ROR-alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P35398. Use UniProt P35398 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35398 as the stable identity anchor, then attach disease evidence before program review.
Nuclear receptor ROR-alpha
Review this target as Nuclear receptor ROR-alpha, mapped to UniProt P35398. Sequence length is 523 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nuclear receptor ROR-alpha as ChEMBL target CHEMBL5868, mapped to UniProt P35398. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Nuclear receptor ROR-alpha is the right protein anchor across sources, using UniProt P35398 as the stable mapping.
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| Preferred Name | Nuclear receptor ROR-alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35398 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nuclear receptor ROR-alpha |
| UniProt Accession | P35398 |
| Component Type | Protein |
| Sequence Length | 523 aa |
Nuclear receptor ROR-alpha
Review this target as Nuclear receptor ROR-alpha, mapped to UniProt P35398. Sequence length is 523 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL497834 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL497207 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL1278177 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL3314003 | 7.54 | EC50 | 29.0 | Preclinical |
| CHEMBL3617295 | 7.07 | EC50 | 86.0 | Preclinical |
| CHEMBL4225808 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL62136 | 6.88 | Ki | 132.0 | Preclinical |
| CHEMBL3094388 | 6.76 | Ki | 172.0 | Preclinical |
| CHEMBL3617309 | 6.7 | EC50 | 200.0 | Preclinical |
| CHEMBL38 | 6.7 | IC50 | 199.53 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 61 | 70 | 5.5 |
| single protein format | 49 | 57 | 5.3 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 2 | 6.2 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 5 | 5.4 |