Heat shock factor protein 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q00613. Use UniProt Q00613 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q00613 as the stable identity anchor, then attach disease evidence before program review.
Heat shock factor protein 1
Review this target as Heat shock factor protein 1, mapped to UniProt Q00613. Sequence length is 529 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Heat shock factor protein 1 as ChEMBL target CHEMBL5869, mapped to UniProt Q00613. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Heat shock factor protein 1 is the right protein anchor across sources, using UniProt Q00613 as the stable mapping.
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| Preferred Name | Heat shock factor protein 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q00613 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Heat shock factor protein 1 |
| UniProt Accession | Q00613 |
| Component Type | Protein |
| Sequence Length | 529 aa |
Heat shock factor protein 1
Review this target as Heat shock factor protein 1, mapped to UniProt Q00613. Sequence length is 529 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4070633 | 8.55 | IC50 | 2.8 | Preclinical |
| CHEMBL2103840 | 8.15 | IC50 | 7.0 | Clinical |
| CHEMBL4063330 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL3975567 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL3937369 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4087666 | 7.73 | IC50 | 18.62 | Preclinical |
| CHEMBL4102297 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL3911352 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL3964729 | 7.41 | IC50 | 39.0 | Preclinical |
| CHEMBL3972065 | 7.35 | IC50 | 45.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 93 | 88 | 5.8 |
| single protein format | 6 | 2 | 5.4 |
| assay format | 5 | 3 | 5.0 |