G-protein coupled estrogen receptor 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q99527. Use UniProt Q99527 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q99527 as the stable identity anchor, then attach disease evidence before program review.
G-protein coupled estrogen receptor 1
Review this target as G-protein coupled estrogen receptor 1, mapped to UniProt Q99527. Sequence length is 375 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats G-protein coupled estrogen receptor 1 as ChEMBL target CHEMBL5872, mapped to UniProt Q99527. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | G-protein coupled estrogen receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q99527 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G-protein coupled estrogen receptor 1 |
| UniProt Accession | Q99527 |
| Component Type | Protein |
| Sequence Length | 375 aa |
G-protein coupled estrogen receptor 1
Review this target as G-protein coupled estrogen receptor 1, mapped to UniProt Q99527. Sequence length is 375 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4448852 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL5964875 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL5979005 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL5835059 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL5841693 | 9.54 | IC50 | 0.29 | Preclinical |
| CHEMBL135 | 9.52 | EC50 | 0.3 | Approved |
| CHEMBL5904942 | 9.51 | IC50 | 0.31 | Preclinical |
| CHEMBL5740053 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL5827662 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL5920005 | 9.48 | IC50 | 0.33 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 22 | 6 | 7.2 |
| assay format | 2 | 3 | 8.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 3 | 8.1 |
| single protein format | 8 | 4 | 7.6 |
| assay format | 2 | 85 | 8.5 |