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Target Snapshot

CHEMBL5873 Target Snapshot

Solute carrier family 2, facilitated glucose transporter member 2 · SINGLE PROTEIN · Homo sapiens

481Compounds
12Assays
0Approved Drugs
256.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P11168. Use UniProt P11168 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P11168 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Solute carrier family 2, facilitated glucose transporter member 2 as ChEMBL target CHEMBL5873, mapped to UniProt P11168. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Solute carrier family 2, facilitated glucose transporter member 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5873
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P11168
Solute carrier family 2, facilitated glucose transporter member 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Solute carrier family 2, facilitated glucose transporter member 2 is the right protein anchor across sources, using UniProt P11168 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSolute carrier family 2, facilitated glucose transporter member 2
UniProt AccessionP11168
Component TypeProtein
Sequence Length524 aa

Solute carrier family 2, facilitated glucose transporter member 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Solute carrier family 2, facilitated glucose transporter member 2, mapped to UniProt P11168. Sequence length is 524 aa.

Mapped IDP11168
Review nameSolute carrier family 2, facilitated glucose transporter member 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC50253.0
KI2.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3781913 7.68 IC50 21.0 Preclinical
CHEMBL3781149 7.22 IC50 60.0 Preclinical
CHEMBL3781331 7.0 IC50 100.0 Preclinical
CHEMBL3780717 6.66 IC50 220.0 Preclinical
CHEMBL3780372 6.29 IC50 510.0 Preclinical
CHEMBL3780756 6.22 IC50 600.0 Preclinical
CHEMBL3780470 6.06 IC50 880.0 Preclinical
CHEMBL3780772 6.05 IC50 900.0 Preclinical
CHEMBL3781835 6.02 IC50 950.0 Preclinical
CHEMBL3781347 6.0 IC50 1000.0 Preclinical
Distribution

pChEMBL Value Distribution

69
5.0
15
5.5
6
6.0
1
6.5
2
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
114
Tested Compounds
2
Assay Types
Binding — 11 assays, 114 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 113 5.2
single protein format 3 1 5.0
Functional — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine