Interleukin-2 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P60568. Use UniProt P60568 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P60568 as the stable identity anchor, then attach disease evidence before program review.
Interleukin-2
Review this target as Interleukin-2, mapped to UniProt P60568. Sequence length is 153 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Interleukin-2 as ChEMBL target CHEMBL5880, mapped to UniProt P60568. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Interleukin-2 is the right protein anchor across sources, using UniProt P60568 as the stable mapping.
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| Preferred Name | Interleukin-2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P60568 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Interleukin-2 |
| UniProt Accession | P60568 |
| Component Type | Protein |
| Sequence Length | 153 aa |
Interleukin-2
Review this target as Interleukin-2, mapped to UniProt P60568. Sequence length is 153 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL395414 | 10.54 | Kd | 0.0289 | Clinical |
| CHEMBL3289607 | 8.59 | Kd | 2.59 | Preclinical |
| CHEMBL3646774 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3646776 | 8.19 | IC50 | 6.4 | Preclinical |
| CHEMBL4857063 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL5205694 | 8.03 | EC50 | 9.4 | Preclinical |
| CHEMBL5087453 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4868242 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL5560228 | 7.94 | EC50 | 11.56 | Preclinical |
| CHEMBL5090091 | 7.89 | IC50 | 13.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 41 | 6.3 |
| tissue-based format | 10 | 11 | 7.2 |
| cell-based format | 8 | 47 | 6.9 |
| organism-based format | 3 | 0 | — |
| assay format | 2 | 21 | 6.3 |
| cell-free format | 1 | 0 | — |