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Target Snapshot

CHEMBL5903 Target Snapshot

Activin receptor type-1 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
2,352Compounds
271Assays
12Approved Drugs
3,059.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Activin receptor type-1 shows approved-linked disease relevance led by bone disease. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q04771. Start with bone disease, then reuse UniProt Q04771 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with bone disease, then reuse UniProt Q04771 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs
Open source guide
Disease program
bone disease

Activin receptor type-1 shows approved-linked disease relevance led by bone disease. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with bone disease because it currently carries approved-linked support. Linked drugs include DIBOTERMIN ALFA, EPTOTERMIN ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Activin receptor type-1 as ChEMBL target CHEMBL5903, mapped to UniProt Q04771. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Activin receptor type-1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5903
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q04771
Activin receptor type-1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Activin receptor type-1 is the right protein anchor across sources, using UniProt Q04771 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why bone disease is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameActivin receptor type-1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ04771
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelActivin receptor type-1
UniProt AccessionQ04771
Component TypeProtein
Sequence Length509 aa

Activin receptor type-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Activin receptor type-1, mapped to UniProt Q04771. Sequence length is 509 aa.

Mapped IDQ04771
Review nameActivin receptor type-1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Activin receptor type-1 shows approved-linked disease relevance led by bone disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
bone disease
2 linked drugs · 2 direct · 2 efficacy
Linked drugDIBOTERMIN ALFA
Linked drugEPTOTERMIN ALFA
Approved-linked Approved
tibia fracture
2 linked drugs · 2 direct · 2 efficacy
Linked drugDIBOTERMIN ALFA
Linked drugEPTOTERMIN ALFA
Approved-linked Approved
Fracture Fixation, Internal
1 linked drug · 1 direct · 1 efficacy
Linked drugDIBOTERMIN ALFA
Approved-linked Approved
myeloproliferative disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugMOMELOTINIB DIHYDROCHLORIDE MONOHYDRATE
Approved-linked Approved
polycythemia vera
1 linked drug · 1 direct · 1 efficacy
Linked drugPACRITINIB CITRATE
Approved-linked Approved
primary myelofibrosis
1 linked drug · 1 direct · 1 efficacy
Linked drugPACRITINIB CITRATE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with bone disease because it currently carries approved-linked support. Linked drugs include DIBOTERMIN ALFA, EPTOTERMIN ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasebone disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

12
Approved
8
Phase III
15
Phase II
11
Phase I
Assay Mix

Activity Type Distribution

IC502,323.0
KI357.0
EC508.0
KD371.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5184000 9.07 IC50 0.85 Preclinical
CHEMBL5181536 9.01 IC50 0.98 Preclinical
CHEMBL4790396 9.0 IC50 1.0 Preclinical
CHEMBL1230714 8.96 IC50 1.1 Preclinical
CHEMBL3818173 8.92 IC50 1.2 Preclinical
CHEMBL5199417 8.92 IC50 1.2 Preclinical
CHEMBL5961222 8.89 IC50 1.3 Preclinical
CHEMBL5186341 8.89 IC50 1.3 Preclinical
CHEMBL5181872 8.89 IC50 1.3 Preclinical
CHEMBL3752910 8.82 Kd 1.506 Preclinical
Distribution

pChEMBL Value Distribution

44
5.0
135
5.5
284
6.0
284
6.5
371
7.0
468
7.5
159
8.0
56
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MOMELOTINIB
CHEMBL1078178
Approved 2023
Properties Compare Identifier
PACRITINIB
CHEMBL2035187
Approved 2022
Properties Compare Identifier
FEDRATINIB
CHEMBL1287853
Approved 2019
Properties Compare Identifier
LORLATINIB
CHEMBL3286830
Approved 2018
Properties Compare Identifier
GILTERITINIB
CHEMBL3301622
Approved 2018
Properties Compare Identifier
NINTEDANIB
CHEMBL502835
Approved 2014
Properties Compare Identifier
VANDETANIB
CHEMBL24828
Approved 2011
Properties Compare Identifier
CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

271
Total Assays
1,073
Tested Compounds
3
Assay Types
Binding — 265 assays, 1,073 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 202 766 7.1
cell-based format 29 259 7.2
assay format 28 27 6.6
subcellular format 6 21 6.6
Functional — 4 assays, 149 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 149 5.9
ADME — 2 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 2 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine