Membrane-bound transcription factor site-1 protease · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q14703. Use UniProt Q14703 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14703 as the stable identity anchor, then attach disease evidence before program review.
Membrane-bound transcription factor site-1 protease
Review this target as Membrane-bound transcription factor site-1 protease, mapped to UniProt Q14703. Sequence length is 1052 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Membrane-bound transcription factor site-1 protease as ChEMBL target CHEMBL5916, mapped to UniProt Q14703. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Membrane-bound transcription factor site-1 protease |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14703 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Membrane-bound transcription factor site-1 protease |
| UniProt Accession | Q14703 |
| Component Type | Protein |
| Sequence Length | 1052 aa |
Membrane-bound transcription factor site-1 protease
Review this target as Membrane-bound transcription factor site-1 protease, mapped to UniProt Q14703. Sequence length is 1052 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL391935 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL233987 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL233799 | 7.43 | IC50 | 37.0 | Preclinical |
| CHEMBL233421 | 7.02 | IC50 | 95.0 | Preclinical |
| CHEMBL233422 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL233609 | 6.85 | IC50 | 140.0 | Preclinical |
| CHEMBL233610 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL233611 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL394028 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL393989 | 6.51 | IC50 | 310.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 21 | 6.4 |
| single protein format | 1 | 6 | 4.5 |