Ubiquitin-like modifier-activating enzyme 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P22314. Use UniProt P22314 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22314 as the stable identity anchor, then attach disease evidence before program review.
Ubiquitin-like modifier-activating enzyme 1
Review this target as Ubiquitin-like modifier-activating enzyme 1, mapped to UniProt P22314. Sequence length is 1058 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ubiquitin-like modifier-activating enzyme 1 as ChEMBL target CHEMBL5924, mapped to UniProt P22314. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ubiquitin-like modifier-activating enzyme 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P22314 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ubiquitin-like modifier-activating enzyme 1 |
| UniProt Accession | P22314 |
| Component Type | Protein |
| Sequence Length | 1058 aa |
Ubiquitin-like modifier-activating enzyme 1
Review this target as Ubiquitin-like modifier-activating enzyme 1, mapped to UniProt P22314. Sequence length is 1058 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5747752 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5759269 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5768102 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5780833 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5803994 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5828810 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5832385 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5864078 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5887314 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL5918592 | 7.26 | IC50 | 55.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 20 | 33 | 6.7 |
| cell-based format | 10 | 2 | 6.2 |
| assay format | 8 | 1 | 6.3 |