Serine/threonine-protein kinase PLK2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9NYY3. Use UniProt Q9NYY3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NYY3 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase PLK2
Review this target as Serine/threonine-protein kinase PLK2, mapped to UniProt Q9NYY3. Sequence length is 685 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase PLK2 as ChEMBL target CHEMBL5938, mapped to UniProt Q9NYY3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase PLK2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NYY3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase PLK2 |
| UniProt Accession | Q9NYY3 |
| Component Type | Protein |
| Sequence Length | 685 aa |
Serine/threonine-protein kinase PLK2
Review this target as Serine/threonine-protein kinase PLK2, mapped to UniProt Q9NYY3. Sequence length is 685 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL513909 | 9.09 | Kd | 0.81 | Clinical |
| CHEMBL1094477 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL2205426 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL513909 | 8.54 | IC50 | 2.92 | Clinical |
| CHEMBL4166771 | 8.47 | IC50 | 3.4 | Preclinical |
| CHEMBL4592698 | 8.4 | IC50 | 3.98 | Preclinical |
| CHEMBL522618 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4454222 | 8.33 | IC50 | 4.72 | Preclinical |
| CHEMBL4171770 | 8.31 | IC50 | 4.88 | Preclinical |
| CHEMBL1233528 | 8.3 | IC50 | 5.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 221 | 126 | 6.6 |
| assay format | 28 | 73 | 7.0 |
| cell-based format | 13 | 20 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 8.0 |